What is it about?
Cells use signaling pathways to receive, process, and respond to signals in their environment. The signaling pathways are made of molecular on-off switches. When a signal arrives, molecular switches may be switched on by activators, or their off state maintained by repressors may be relieved. The former case is like stepping on the accelerator in a car; the latter is like removing the foot from the brake. Our work compares different properties of signaling output of an activation-controlled switch versus that of a de-repression-controlled switch, providing insights into the advantages of each of these switch architectures. The results from our analysis should find relevance in designing drugs, synthetic biology, and understanding evolution.
Photo by Philipp Katzenberger on Unsplash
Why is it important?
Our finding show that signaling pathways in which signaling is initiated through activation respond differently from pathways that are activated by de-repression. These different properties may confer evolutionary benefits depending on environmental conditions.
Read the Original
This page is a summary of: Molecular switch architecture determines response properties of signaling pathways, Proceedings of the National Academy of Sciences, March 2021, Proceedings of the National Academy of Sciences,
You can read the full text:
The following have contributed to this page