What is it about?
We identified a brown fat-enriched enzyme that, when depleted, promotes thermogenesis, energy expenditure, and insulin sensitivity in mice.
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Why is it important?
Our findings uncover PHOSPHO-1 as a novel regulator of adipose tissue thermogenesis, a process dissipates energy as heat and combats obesity. Therefore, PHOSPHO1 can be further exploited to develop innovative approaches to manage obesity and its related metabolic syndrome.
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This page is a summary of: Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis, Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1916550117.
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