What is it about?
We found that iron regulatory protein 2-deficiency switches cellular metabolic pathways from oxidative phosphorylation (OXPHOS) to aerobic glycolysis. We further revealed that Irp2 deficiency induces the expression of Hif1α and Hif2α; Hif1α enhances aerobic glycolysis by upregulating its target genes related to the glycolytic pathway, and Hif2α suppresses mitochondrial Fe–S biosynthesis and OXPHOS.
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Why is it important?
Iron regulatory protein 2 deficiency causes symptoms of neurological disorders.
Perspectives
This identified mechanism implies that high-energy-need tissues, such as the central nervous system, could be affected when Irp2 is deficient, leading to neurological disorders.
Kuanyu Li
Nanjing University
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This page is a summary of: Iron regulatory protein 2 modulates the switch from aerobic glycolysis to oxidative phosphorylation in mouse embryonic fibroblasts, Proceedings of the National Academy of Sciences, April 2019, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1820051116.
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