What is it about?
To understand how the progenitor cells (stem) from newborn mouse skin were regulated to form skin with appendages (like hair follicles). Using the 3D in vitro organoid model, the self-organization ability of the newborn mouse cells was learned and was used to partially restore the adult mouse cells to form hairs
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Why is it important?
Previous studies were focusing on using different sources of cells to regenerate skin and hair follicles with inconsistent outcome. This multi-disciplinary approach helps to learn the nature of self-organization ability of the newborn mouse cells comprehensively. Through such learning, the regenerative ability of the adult mouse cells could be partially restored. This finding will provide one step closer in regenerating human skin and human hair follicles with the potential of the same to be applied in treating burn injury and alopecia
Perspectives
This study opens a new avenue to improve the ability of adult skin cells to form a fully functional skin, with clinical applications. The principles uncovered here are likely to function in other organ systems and will inspire us to view organoid morphogenesis, embryogenesis, and regeneration differently. The application of these findings will enable the rescue of robust hair formation in adult skin cells, thus eventually helping patients in the context of regenerative medicine
Dr. Mingxing Lei
China Medical University
Read the Original
This page is a summary of: Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells, Proceedings of the National Academy of Sciences, August 2017, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1700475114.
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