Structural revelations of the human proton channel

What is it about?

I discuss an EPR study of the human proton channel by Li et al (2015) PNAS. They propose that hHV1 opens by the S4 helix moving up "one-click." Most folks thought that all three Arg in the hHV1 S4 segment moved from internally-accessible to externally-accessible during channel opening. The new one-click model is consistent with our finding (Kulleperuma et al, 2013) that the third S4 Arg - R211H remains accessible to internal Zn2+ even in the open state

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