What is it about?
Uses a special kind of very sparse (parsimonious) feature selection to choose a small number of genes from around 35,000 that are important when stem cells are forced to become bone when exposed to strontium ions
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Why is it important?
It provides an explanation of how an effective treatment for osteoporosis, and other conditions causing bone loss, works. It also provides a rational way to design more effective drugs for growing bone
Perspectives
This was a very enjoyable collaboration with Molly Stevens' team at Imperial College, London. I'm glad this novel, unbiased method for uncovering new biochemical mechanisms was so useful.
Professor Dave A Winkler
La Trobe University
Read the Original
This page is a summary of: Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials, Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1419799112.
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