What is it about?
A protein tag that can be added to a protein drug to increase the time it stays in the body.
Featured Image
Why is it important?
A drug with a long half-life needs less frequent administration, and gives a more even dose over time. Too high doses can be toxic and too low doses are inefficient.
Perspectives
This publication shows the technical possibilities and power of phage display. A protein with pH-dependent binding to the FcRn receptor mimicking IgG1 was selected for in two weeks. The pH-dependent switch in IgG1 probably took several million years for evolution too achieve.
Dr Johan Seijsing
Stockholm University
Read the Original
This page is a summary of: An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein, Proceedings of the National Academy of Sciences, November 2014, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1417717111.
You can read the full text:
Contributors
The following have contributed to this page
