What is it about?
three proline- and acidic amino acid-rich basic leucine zipper proteins also play a key role in circadian lipid metabolism by influencing the rhythmic expression and activity of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) leading to a cyclic release of fatty acids from thioesters.
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Why is it important?
the clock system by activating PPARα receptor then stimulates the transcription of genes encoding proteins involved in the uptake and/or metabolism of lipids, cholesterol, and glucose metabolism.
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This page is a summary of: Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor α (PPARα) activity, Proceedings of the National Academy of Sciences, March 2011, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1002862108.
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