What is it about?
RXR activation of RXR/LXR reduces atherosclerosis by increasing HDL turn over and reverse cholesterol transport, in addition PPAR alpha/gamma coagonist also reduced atherosclerosis
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Why is it important?
proof of concept that nuclear receptor modulators can reduce atherosclerosis development in vivo
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This page is a summary of: Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor, Proceedings of the National Academy of Sciences, February 2001, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.041609298.
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