What is it about?
Long noncoding RNAs, or lncRNAs, are a type of RNA that help control many important processes in cells, but the role of most lncRNAs is still unknown. To understand how they influence the immune system, we studied lncRNAs in cytotoxic T cells, which are immune cells that fight infections. By removing six lncRNAs in mice, we discovered that one called Rroid2 is especially important.
Featured Image
Photo by National Institute of Allergy and Infectious Diseases on Unsplash
Why is it important?
Without Rroid2, cytotoxic T cells do not expand properly, work as effectively, or develop into memory cells that “remember” infections. Rroid2 achieves this by carefully regulating key genes and signaling pathways inside these cells. Overall, this work reveals how Rroid2 helps guide the development and function of immune cells, shedding light on a new mechanism that controls how the body fights and remembers infections.
Read the Original
This page is a summary of: Rroid2
regulates effector-to-memory CD8
+
T cell differentiation during infection in vivo, Proceedings of the National Academy of Sciences, November 2025, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2503450122.
You can read the full text:
Contributors
The following have contributed to this page
