What is it about?
USP7 is an important enzyme whose activity is tightly controlled in cells. Using advanced NMR techniques, researchers gained a rare glimpse into how the enzyme’s movements regulate its function. They discovered that a mutation linked to a rare neurodevelopmental disorder increases these movements, causing the enzyme to become overactive.
Featured Image
Photo by Chris Liverani on Unsplash
Why is it important?
USP7 dysfunction is linked to cancer and neurodevelopmental disorders. These findings reveal how altered enzyme dynamics contribute to disease and open new avenues for therapeutic development.
Perspectives
I hope our findings help shed more light on USP7-related diseases and lead to better ways to diagnose and treat them.
Irina Bezsonova
University of Connecticut
Read the Original
This page is a summary of: Activation dynamics of ubiquitin-specific protease 7, Proceedings of the National Academy of Sciences, May 2025, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2426632122.
You can read the full text:
Contributors
The following have contributed to this page
