What is it about?
microRNAs are small RNAs that regulate the expression of specific target genes. miR-137 has been highly associated with neurological disorders as well as cancer. Here, we reveal a new role for miR-137 in regulating insulin signaling and energy homeostasis.
Featured Image
Photo by DIGITALE on Unsplash
Why is it important?
Maintaining energy homeostasis in the face of changing nutrient availability is critical for organismal survival. Multiple signaling pathways contribute to sustaining energy homeostasis, including the insulin signaling pathway. We introduce the microRNA, miR-137, as a new regulator of insulin signaling. Because miR-137 has been highly associated with neuropsychiatric disorders, which often have co-morbidities involving dysfunctional insulin signaling, our findings may provide a basis for these relationships as well as ideas for ways to modulate insulin signaling in various disorders.
Perspectives
I hope this research will provide more interest in the value of Drosophila to investigate how conserved molecular regulation of signaling affects whole organismal physiology.
Susan Tsunoda
Colorado State University
Read the Original
This page is a summary of: miR-137
regulates PTP61F, affecting insulin signaling, metabolic homeostasis, and starvation resistance in
Drosophila, Proceedings of the National Academy of Sciences, January 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2319475121.
You can read the full text:
Contributors
The following have contributed to this page
