What is it about?
We examined mutations that E. coli bacteria picked up during antibiotic treatment in patients. We found that some mutations led to increased production of antibiotic tolerant persister subpopulations. These strains also showed decreased susceptibility to antibiotics in our murine model of infection.
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Why is it important?
This paper provides important evidence that persister cell formation is contributing to antibiotic treatment failure in the clinic.
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This page is a summary of: In-patient evolution of a high-persister
Escherichia coli
strain with reduced in vivo antibiotic susceptibility, Proceedings of the National Academy of Sciences, January 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2314514121.
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