What is it about?
Plasma membrane heterogeneity is a key biophysical regulatory principle of membrane protein dynamics. In this work, we developed a high-spatial resolved DNA-origami-based nanoheater system to manipulate the local lipid environmental temperature under near-infrared laser illumination. This high spatial-resolved, raft/non-raft domain-targeted nanodevices not only alters local membrane fluidity but also interferes with membrane phase separation through highly specified manipulation
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Why is it important?
Although the lipid raft hypothesis has gained great success, a direct link between membrane heterogeneity and cell biological processes remains poorly understood. This is, at least in part, due to the shortage of high spatial-resolved molecule tools to interfere with the membrane heterogeneity and find its correlation to cell functions. We provided, for the first time, a high spatial-solved, remote-controlled, domain-targeted, and reversible molecule tool to alter membrane heterogeneity through physical property change. This molecule tool enables to control signal pathway change, possibly through regulating dynamic assemblies and function of membrane-bound receptors, thereby featuring the capability to build a direct, unexplored correlation between membrane heterogeneity and cell function, which holds great potential in therapy.
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This page is a summary of: High spatial-resolved heat manipulating membrane heterogeneity alters cellular migration and signaling, Proceedings of the National Academy of Sciences, November 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2312603120.
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