What is it about?
A devastating characteristic of cancer is its ability to spread and invade other parts of the body. Using a live single cell biosensor, this study shows that MALAT1, a long non-coding RNA, regulates collective cancer invasion. The results demonstrate that the lncRNA MALAT1 is dynamically regulated in the invading fronts of cancer cells and patient-derived spheroids.
Photo by National Cancer Institute on Unsplash
Why is it important?
The finding may provide a promising prognostic marker and therapeutic target for combating cancer metastasis.
Read the Original
This page is a summary of: Long noncoding RNA MALAT1 is dynamically regulated in leader cells during collective cancer invasion, Proceedings of the National Academy of Sciences, June 2023, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2305410120.
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