What is it about?

The research, led by a team of experts in virology and computational biology, shed light on the underlying mechanisms contributing to the prolonged fatigue experienced by a subset of patients who have battled viral illnesses. Our study have made significant strides in understanding the intricate interplay between viral infections, metabolic disruptions, and the development of post-viral fatigue syndrome in Crimean-Congo hemorrhagic fever virus (CCHFV) infections. The study has uncovered a pivotal connection between the virus, metabolic imbalance, and the debilitating exhaustion that afflicts some individuals long after their recovery.

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Why is it important?

CCHF is on the World Health Organization’s (WHO) list of priority diseases, with a high case fatality rate (up to 40%) and no or insufficient countermeasures. Our study not only offered insights into the progression of the CCHFV infection itself but also unveiled the intricate relationship between the virus and our body's energy and carbon metabolism. The multi-dimensional analysis used in the study provided invaluable insights into the progression of the disease and the body's responses.


The exhaustion that follows viral infections has long puzzled medical professionals. Our research indicates that the disruption in metabolism caused by CCHFV infection could be a driving force behind the development of post-viral fatigue syndrome. The study lays the groundwork for a more comprehensive understanding of post-viral fatigue syndrome across various viral illnesses by unraveling the intricate link between viral infection and metabolic changes. This newfound knowledge could lead to the development of tailored interventions and treatments to address the lingering fatigue that impedes the quality of life.

Ujjwal Neogi
Karolinska Institutet

Read the Original

This page is a summary of: Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection, Proceedings of the National Academy of Sciences, September 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2304722120.
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