What is it about?
Comparative connectomics – the study of neural circuits at synaptic resolution across species or the life span – promises to reveal how evolution modifies the nervous system to shape behavior and perception. Here we compare the synaptic connectome for a color-coding circuit in the human retina with the comparable circuits in both marmoset and macaque monkey.
Photo by Vincent Giersch on Unsplash
Why is it important?
We discover a circuit in human that is absent in the marmoset and show further that for the human retina synaptic motifs do not follow the canonical architecture established in macaque monkey. Our results may help to explain why some aspects of human color perception are not well predicted from physiological studies of macaque monkey visual system.
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This page is a summary of: Comparative connectomics reveals noncanonical wiring for color vision in human foveal retina, Proceedings of the National Academy of Sciences, April 2023, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2300545120.
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