What is it about?
In human cells, DNA and protein form a complex called chromatin. The physical organization of chromatin affects the regulation of gene expression. This paper develops a model of a process known as active loop extrusion that forms chromatin loops. We use physics theory and computer simulations to match experimental data.
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Why is it important?
Our work may provide a framework to help experimentalists engineer specific contacts between genomic locations to regulate gene expression. Our theory explains how biological parameters related to an important protein called cohesin impacts chromatin looping.
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This page is a summary of: Theory of chromatin organization maintained by active loop extrusion, Proceedings of the National Academy of Sciences, May 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2222078120.
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