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T cells recognize pathogen infected cells via human leukocyte antigens (HLA). HLA molecules present peptides derived from pathogens to the T cells. A long standing dogma was that those peptides only bind in a certain orientation to the HLA molecule. In this study we show that peptides can also bind in a reversed orientation to a certain group of HLA molecules. The reverse binding increases the possibilities for T cells to recognize pathogen infected cells and therefore broadens the human T cell repertoire.

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This page is a summary of: Human T cells recognize HLA-DP–bound peptides in two orientations, Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2214331119.
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