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Systemic iron metabolism is key for cellular and organismal function. However, the subcellular regulatory mechanisms of iron homeostasis remain poorly understood. In this study we show the pathophysiological significance of a principal cellular protein quality-control mechanism known as endoplasmic reticulum-associated degradation (ERAD) in systemic iron homeostasis, in part by regulating the abundance of ceruloplasmin, a key ferroxidase.

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This page is a summary of: Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin, Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2212644120.
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