What is it about?

Metformin, the most prescribed drug to treat diabetes, in use for 66 years did not have a clear site and mechanism of action. Our data show that the first and most important site of metformin action is the gut and not the liver. The action in the gut, extracting glucose from circulation to be metabolized in the gut, reduces hyperglycemia and drives the effect in the liver.

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Why is it important?

It describes a new and unique mechanism of metformin action, and through this new mechanism, never previously described to treat diabetes, open new avenues to the the developement of new drugs.


Writing this article was a great pleasure, because our group feel that we are adding new data to the literature and most important describing the real action of an important drug used to treat diabetes.

Mario Saad

Read the Original

This page is a summary of: Metformin acts in the gut and induces gut-liver crosstalk, Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2211933120.
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