What is it about?
This works demonstrates that bacteria alter the position and action of transcription factors in the cell in response to environmental nutrients by post-transcriptional modifications that utilize metabolic intermediates such as acetate and succinate..
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Why is it important?
This is a novel mechanism by which the action of transcription factors in general and the cAMP receptor protein (CRP), in particular, is modified by nutrient availability. It also uncovers a novel interaction between CRP and the dual function peptidase Peptidase A (PepA) and establishes PepA as a global transcription factor in its own right.
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This page is a summary of: Sequestration of a dual function DNA-binding protein by
Vibrio cholerae
CRP, Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2210115119.
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