What is it about?
Protein drugs – insulin being a common example – cannot be taken as pills, because they cannot be properly absorbed by the intestines and released into the body. Here, we have found that a molecule in common strawberries can be given alongside these drugs to boost their uptake into the body and allow them to take full effect when taken by mouth.
Photo by 铮 夏 on Unsplash
Why is it important?
Oral delivery of insulin (and other peptide or protein drugs) could greatly improve patient compliance and treatment successes, but they have previously been hindered by the inability of these drugs to absorb into the body through the intestines. Here, we describe a new use for a naturally occurring chemical – derived from strawberries – that can enable absorption of these drugs with no detectable side effects in the intestines, even after repeated daily dosing for a month.
Read the Original
This page is a summary of: The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2207829119.
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