What is it about?
Glioblastoma multiforme is a devastating brain tumor, which has been impervious to immune interventional therapies. Here, we characterized the phenotype of tumor-infiltrating T cells. We have shown that CD4+ T cells infiltrating the tumor site bear features of T helper 17 (TH17) cells.
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Photo by National Cancer Institute on Unsplash
Why is it important?
The presence of intratumoral TH17 cells may hamper productive anti-tumor immune responses and instead create a milieu permissive to further tumor growth. Local inhibition of TH17 responses may be a prerequisite for efficient anti-tumor immunity in glioblastome multiforme.
Perspectives
This work has been based on a very productive collaboration between the departments of Neurosurgery and Experimental Neuroimmunology. I hope this article will elicit new and testable hypotheses about the next generation of immune interventions in glioblastoma multiforme.
Thomas Korn
Technical University of Munich School of Medicine
Read the Original
This page is a summary of: The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the TH17 lineage in humans, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2206208119.
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