What is it about?

Glioblastoma multiforme is a devastating brain tumor, which has been impervious to immune interventional therapies. Here, we characterized the phenotype of tumor-infiltrating T cells. We have shown that CD4+ T cells infiltrating the tumor site bear features of T helper 17 (TH17) cells.

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Why is it important?

The presence of intratumoral TH17 cells may hamper productive anti-tumor immune responses and instead create a milieu permissive to further tumor growth. Local inhibition of TH17 responses may be a prerequisite for efficient anti-tumor immunity in glioblastome multiforme.

Perspectives

This work has been based on a very productive collaboration between the departments of Neurosurgery and Experimental Neuroimmunology. I hope this article will elicit new and testable hypotheses about the next generation of immune interventions in glioblastoma multiforme.

Thomas Korn
Technical University of Munich School of Medicine

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This page is a summary of: The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the T H 17 lineage in humans, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2206208119.
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