What is it about?
The brain has an amazing capacity to learn and store new memories. Yet, recent studies show that it is also designed to forget memories, to provide for flexibility in decision making as the environment changes. The circuit, cellular, and molecular mechanisms underlying forgetting are largely unknown. We discovered a new gene, named Sickie, that is required for normal forgetting in Drosophila by facilitating the release of dopamine onto neurons that store memory, thereby aiding in the erasure of memory.
Photo by Sander Sammy on Unsplash
Why is it important?
Our studies continue to define cells and molecules that function in the process of active forgetting. We will be in a much better position to design effective therapeutics for memory disorders with increased knowledge about how the brain forgets memories.
Read the Original
This page is a summary of: Active forgetting requires Sickie function in a dedicated dopamine circuit in
Drosophila, Proceedings of the National Academy of Sciences, September 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2204229119.
You can read the full text:
The following have contributed to this page