What is it about?

Epilepsy is a common brain disorder and genetic factors play significant roles in the process by which epilepsy develops. This study identified a novel genetic component for epilepsy, discovered how this novel genetic component contributes to epilepsy, and provided a new therapeutic strategy for epilepsy.

Featured Image

Why is it important?

Our findings show an unexpected subtype of inhibitory neurons contribute much more significantly to epilepsy than other well-known subtypes of inhibitory neurons through a molecule regulating genetic diversity and stability.


This article shows the same molecule can work dramatically differently in distinct cell types or even among subtypes of the same cell type. Precise mouse genetic tools are critical for this type of research.

Hsien-Sung Huang
National Taiwan University

Read the Original

This page is a summary of: Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2203632119.
You can read the full text:



The following have contributed to this page