What is it about?
Epilepsy is a common brain disorder and genetic factors play significant roles in the process by which epilepsy develops. This study identified a novel genetic component for epilepsy, discovered how this novel genetic component contributes to epilepsy, and provided a new therapeutic strategy for epilepsy.
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Why is it important?
Our findings show an unexpected subtype of inhibitory neurons contribute much more significantly to epilepsy than other well-known subtypes of inhibitory neurons through a molecule regulating genetic diversity and stability.
Perspectives
This article shows the same molecule can work dramatically differently in distinct cell types or even among subtypes of the same cell type. Precise mouse genetic tools are critical for this type of research.
Hsien-Sung Huang
National Taiwan University
Read the Original
This page is a summary of: Neuronal splicing regulator RBFOX3 mediates seizures via regulating
Vamp1
expression preferentially in NPY-expressing GABAergic neurons, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2203632119.
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