What is it about?
We report the high-resolution structure of PLA2R with its domain orientation and define key regions within the domain epitope critical for its immunogenicity in MN. We generated a minimal peptide necessary for binding autoantibodies with high affinity for developing future therapies.
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Why is it important?
This synthetic peptide of the epitope offers exciting prospects for drug discovery and a more targeted treatment for patients with MN, avoiding the need for immunosuppression.
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This page is a summary of: Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch, Proceedings of the National Academy of Sciences, July 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2202209119.
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