What is it about?
[4Fe4S] cluster complexes are biological cofactors crucial to all domains of life. Among many, their most important role is electron transfer. Here, we disclose a 50-year long standing challenge in the field of bioinorganic chemistry, by preparing and characterizing a series of synthetic [4Fe4S] complexes spanning the largest number of possible oxidation states.
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Why is it important?
Synthetic models of [4Fe4S] clusters were first discovered in the late 60s. Since then, comparing the spectroscopic fingerprints of synthetic models with data recorded on biological samples has enabled our modern-day understanding of electron transfer in iron-sulfur proteins. The series of models presented here is the first complete and truly systematic one, providing a unique library for biochemists to work with.
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This page is a summary of: A complete biomimetic iron-sulfur cubane redox series, Proceedings of the National Academy of Sciences, July 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2122677119.
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