What is it about?

Electrical signals generated by nerve cells in the retina were recorded non-invasively from around 200 healthy individuals. We found that certain electrical signals (that arise after stimulation of the cells that are active in daylight conditions) differ depending on the presence of a genetic risk factor that has been linked to short-sightedness (myopia).

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Why is it important?

Myopia is increasing dramatically worldwide (and this can be linked to sight-threatening complications). This study is a step forward in understanding the possible mechanisms that might be causing myopia.

Perspectives

This study shows, amongst other things, how analysis of retinal recordings from healthy individuals together with those from patients with rare retinal diseases, can be combined to shed light on the potential role of different retinal signals in the development of a common eye condition.

Omar Mahroo
University College London

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This page is a summary of: Electrical responses from human retinal cone pathways associate with a common genetic polymorphism implicated in myopia, Proceedings of the National Academy of Sciences, May 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2119675119.
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