What is it about?
We associate discomfort with information that coincide with the discomfort to form a memory, and use that memory to guide future behavior in order to avoid that discomfort. This aversive associative learning is a fundamental feature of animal learning and behavior. By studying a tiny roundworm, we identify nerve cells and signals that are important for this learning.
Photo by Vlad Tchompalov on Unsplash
Why is it important?
The nerve signal identified in this work is also present in higher animals, including mammals and human. Understanding how this nerve signal regulates memory contributes to a deeper insight into the mechanism of learning and memory related to stress.
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This page is a summary of: A serotonergic circuit regulates aversive associative learning under mitochondrial stress in
C. elegans, Proceedings of the National Academy of Sciences, March 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2115533119.
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