What is it about?

We associate discomfort with information that coincide with the discomfort to form a memory, and use that memory to guide future behavior in order to avoid that discomfort. This aversive associative learning is a fundamental feature of animal learning and behavior. By studying a tiny roundworm, we identify nerve cells and signals that are important for this learning.

Featured Image

Why is it important?

The nerve signal identified in this work is also present in higher animals, including mammals and human. Understanding how this nerve signal regulates memory contributes to a deeper insight into the mechanism of learning and memory related to stress.


Our study demonstrates the usefulness of a simpler organism in dissecting the mechanisms of memory, learning and cognition.

Chun-Liang Pan
National Taiwan University

Read the Original

This page is a summary of: A serotonergic circuit regulates aversive associative learning under mitochondrial stress in C. elegans, Proceedings of the National Academy of Sciences, March 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2115533119.
You can read the full text:




The following have contributed to this page