What is it about?

Parkinson's disease and dementia with Lewy bodies are neurodegenerative diseases that involve a buildup of protein aggregates in the brain. The method described here provides a way to measure and understand how these aggregates interact with other molecules in the brain.

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Why is it important?

The method may help understand the fundamental molecular features of the neurodegenerative disease process.

Perspectives

A powerful approach to understand molecular features of pathological inclusions in neurodegenerative disease.

Bryan Killinger
Rush University

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This page is a summary of: In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain, Proceedings of the National Academy of Sciences, January 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2114405119.
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