What is it about?
We found that acetylation transforms SOD2, a tumor suppressor, into a cancer promoting enzyme.
Photo by National Cancer Institute on Unsplash
Why is it important?
1) SOD2 has been known to have a dichotomous role as a tumor suppressor in healthy cells and a pro-cancer enzyme in established tumors. Our study shows that acetylation, a modification associated with metabolic dysfunction, promotes structural changes to the enzyme directly associated with this change in function. 2) The structural uniqueness of FeSOD2 as well as its localization to the nucleus may enable the development of better, targeted therapies for breast cancer.
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This page is a summary of: Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity, Proceedings of the National Academy of Sciences, July 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2110348119.
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