What is it about?

Many severe lung diseases may lead to Pulmonary fibrosis, a common fatal disease, which is characterized by destruction of normal lung tissue, and ultimate respiratory failure. Although this lung disease is thought to be associated with destructed lung tissue structure and altered lung functions, its pathological causes remain unclear, and effective treatments for stoping the progress of this disease are still lacking. A better understanding what is the cause of this disease is crucial for designing new treatment for this disease. Our study showed that LRRK2 is an important molecule that is crucial to maintain normal lung function, and to prevent the development of fibrotic lung disease.

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Why is it important?

This study uncovered the important biological roles of the molecule LRRK2 in maintaining lung homeostasis and in fibrotic lung disease pathogenesis, which provides potential targets for designing novel therapeutic strategies for the treatment of pulmonary fibrosis.


The findings of our study provide new insights into the pathological mechanisms of pulmonary fibrosis, which may have potential for translation into the development of new treatments. I hope this study will atrract interests of researchers and clinicians.

Li Wu
Institute for Immunology Tsinghua University

Read the Original

This page is a summary of: LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis, Proceedings of the National Academy of Sciences, August 2021, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2106685118.
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