What is it about?
A China-U.S. study led by scientists at China Pharmaceutical University (CPU) and Harvard University has identified a new small-molecule antagonist of the stimulator of interferon genes (STING) signaling pathway, SN-011, and shown it to be safe, effective and specific in STING-driven inflammatory diseases.
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Why is it important?
SN-011 was demonstrated to inhibit activation of wild-type (WT) and SAVI-associated STING GOF mutants. SN-011 was not only well tolerated, but also shown to ameliorate autoimmune pathology and significantly prevent death in Trex1-deficient mice. It potentially could be improved for treating inflammatory and auto-immune diseases.
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This page is a summary of: STING inhibitors target the cyclic dinucleotide binding pocket, Proceedings of the National Academy of Sciences, June 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2105465118.
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