What is it about?

Cancer cell killing without side effects.

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Why is it important?

CINDELA (Cancer Specific INDEL Attacker) strategy can generate DNA double strand breaks at insertion-deletion mutations found only in cancer by CRISPR-Cas9. Similar to radiation or chemotherapy, CINDELA can kill cancer cells by inducing DNA double strand breaks. However, CINDELA only creates DNA double strand breaks, it will not produce side effects like radiation and chemotherapy.

Perspectives

CINDELA uses most recent advances in biomedical research; Cancer genome analysis and CRISPR-Cas9. Combining those recent advances, a novel strategy of CINDELA will become potential personalized precision cancer therapy method.

Kyungjae Myung
Institute for Basic Science

Read the Original

This page is a summary of: Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9, Proceedings of the National Academy of Sciences, February 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2103532119.
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