What is it about?
The proteasome is a molecular machine inside all of our cells that unfolds and degrades proteins the cell doesn't want anymore. As part of the degradation process, the proteasome switches from a conformation or shape that can accept proteins to be degraded to a conformation better suited for pulling the substrates into a central degradation chamber. In this work we used a fluorescence technique to examine the proteasome's conformation and found that making changes to the proteasome that disfavor the pulling conformation also decrease the proteasome's ability to unfold and degrade substrates.
Photo by Mila Di Bella on Unsplash
Why is it important?
The proteasome is an important drug target in diseases ranging from cancer to neurodegeneration. Current drugs inhibit the proteasome. Controlling the proteasome's conformation might be a way to affect which proteins get degraded by the proteasome without completely inhibiting it.
Read the Original
This page is a summary of: Proteasomal conformation controls unfolding ability, Proceedings of the National Academy of Sciences, June 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2101004118.
You can read the full text:
The following have contributed to this page