What is it about?
Endothelial cells from lung (pulmonary) arteries are important for pulmonary blood pressure regulation. Calcium ions are critical for the normal function of endothelial cells. We found that TRPV4, a protein that allows calcium ions to enter into endothelial cells, maintains low pulmonary blood pressure. Pulmonary hypertension is a serious disorder characterized by high pulmonary blood pressure. Our data show that a loss of endothelial TRPV4 activity raises pulmonary blood pressure in pulmonary hypertension.
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Why is it important?
Endothelial cell TRPV4 is known to have harmful effects in lung injury and edema. Although we knew that TRPV4 is active under healthy conditions, its role in maintaining normal function was unknown. We provide the first evidence that endothelial TRPV4 is essential for maintaining normal pulmonary blood pressure. Data on pulmonary arteries from patients provide clinically relevant information about the impairment of endothelial TRPV4 in pulmonary hypertension. Our results also reveal specific proteins that target endothelial TRPV4 and impair its activity in pulmonary hypertension. This information may help identify new treatment strategies for pulmonary hypertension.
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This page is a summary of: Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension, Proceedings of the National Academy of Sciences, April 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2023130118.
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