What is it about?
We found that the neuron rich layer of tissue on the surface of the brain is filled with low-flow spots, and that there is no possible arrangement of arterioles and venules that could eliminate these spots. Instead, minimizing the influence of low-flow spots creates an optimal ratio of arterioles to venules that is remarkably close to that seen in real brains.
Photo by Robina Weermeijer on Unsplash
Why is it important?
The work shows that due to the low blood flow spots in the cortex, the hydraulics of brain blood flow are both exquisitely complex, surprisingly robust to some forms of damage, and surprisingly vulnerable to other types of damage.
Read the Original
This page is a summary of: Control of low flow regions in the cortical vasculature determines optimal arterio-venous ratios, Proceedings of the National Academy of Sciences, August 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2021840118.
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