What is it about?

Parkinson's disease is a nervous system disorder affecting millions of people worldwide. An abundant neuronal protein alpha-synuclein's non-functional aggregates accumulate in cell during this disease, resulting in abnormal cell to cell communication. The normal physiological function of monomeric alpha-synuclein is still unclear. Here we used biophysical and biochemical approaches to point out a key function of alpha-synuclein monomer in regulating cell to cell communication, which is required to synchronize the overall function of human body.

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Why is it important?

Our study will help to understand the molecular basis of abnormal intercellular communication, during pathological conditions. A few key observations will initiate new cell-based studies and in the future can be extended to the structure-function study of alpha-synuclein in more detail. These are crucial factors to identify better drug targets for the disease in the future.


I hope this article will initiate new in vivo studies to understand the pathogenesis of Parkinson's disease.

Debasis Das
Tata Institute of Fundamental Research

Read the Original

This page is a summary of: α-Synuclein kinetically regulates the nascent fusion pore dynamics, Proceedings of the National Academy of Sciences, August 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2021742118.
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