What is it about?

Endocrine disruptors — environmental pollutants that can cause reproductive, metabolic, or neurological disorders — can potentially become more harmful if mixed. We have used various structural, cellular and in vivo approaches to show how a mixture of three chemicals may disrupt critical cell signaling at concentrations where individual components are considered safe.

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Why is it important?

Our findings may have broad-reaching implications in the fields of toxicology, endocrine disruption, and risk assessment. They may explain part of the low-dose effects of endocrine disruptors and point out the need to consider chemical exposure beyond regulatory framework boundaries.

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This page is a summary of: Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures, Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2020551118.
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