What is it about?

Cancer cells use elaborate strategies to survive chemotherapy, but our understanding of the processes they apply to resolve the cellular stress chemotherapy causes them is limited. We found that overcoming stress can trigger new challenges for the cancer cells that survive chemotherapy, which could potentially be exploited therapeutically.

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Why is it important?

The findings could lead to more effective ways of combining cancer drugs.


This work was a thoroughly enjoyable collaboration between multiple researchers from a diverse range of fields, such as cancer cell biology, biomathematics, and systems biology, which forced us all to be open-minded about the way we do our research.

Holger Auner
Imperial College London

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This page is a summary of: Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs, Proceedings of the National Academy of Sciences, April 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2018229118.
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