Toxin-antitoxin regulates plasmid replication
Photo by Adrian Lange on Unsplash
What is it about?
In this work, we demonstrate the functional significance of a large group of antitoxins on conjugative plasmids: the antitoxin PrpA acts as an novel player in the negative control of plasmid replication, by binding to the iterons in the plasmid origin that inhibits the binding of the replication initiator to the iterons.
Why is it important?
This work shows that the antitoxin can directly regulate plasmid replication, expanding our understanding of the physiological role of TA systems.
The following have contributed to this page: Xiaoxue Wang, Pengxia Wang, and Songwei Ni