What is it about?
Interleukin-17A signaling plays important role in autoimmune diseases and host-defense. The balance between good and bad effects depend upon the 14-3-3zeta presence in the cells. 14-3-3zeta interacts with TRAF5 and regulates its activity. The 14-3-3zeta-TRAF5 axis is a new regulation that helps us understand how IL-17A signaling works.
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Why is it important?
Instead of global inhibition, this new regulation will help design better IL-17A based-therapeutics.
Read the Original
This page is a summary of: 14-3-3ζ–TRAF5 axis governs interleukin-17A signaling, Proceedings of the National Academy of Sciences, September 2020, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2008214117.
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