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This study identifies CREB-1 as a central, previously unrecognized mediator of the benefits associated with calorie restriction (CR). The authors demonstrate that CREB-1 directly upregulates Sirt-1 expression and facilitates its recruitment to DNA, thereby driving the transcription of genes essential for metabolism and neuronal survival. Notably, mice with a forebrain-specific deletion of CREB-1 fail to reap the physiological rewards of CR; these animals exhibit suppressed Sirt-1 levels alongside significant impairments in neuronal plasticity, memory, and social behavior. The findings confirm that CREB-1 acts as a central mediator, linking nutritional status to SIRT1-mediated improvements in brain aging.
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This page is a summary of: A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction, Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1109237109.
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