Incorporating multiscale methylation effects into nucleosome-resolution chromatin models for simulating mesoscale fibers

What is it about?

This study investigates how small chemical changes, called methylation, can affect the way our DNA is packed in cells. We use computer models to show how these changes affect chromatin at different levels: between nearby parts of DNA and across larger regions. We used real human gene data to test our model and found it matches known patterns, like how DNA becomes more loosely packed as people get older. This helps us better understand how these small changes can affect how our genes work.

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