What is it about?

Computational fluid dynamics is used to evaluate the effects of different delivery conditions on deposition efficiency (DE) of drug and delivered drug-laden flow in maxillary sinuses during pulsating bi-directional nasal drug delivery. The local dynamic LES model is two-way coupled with particles to model the airflow and drug transport in CT-based geometry of the nasal cavity.

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Why is it important?

Our findings show that more particles penetrate into the right maxillary sinus than into the left maxillary sinus due to the nosepiece placement in the right nostril, despite the maxillary ostium being larger in the left cavity. The results showed that lower pulsation flow rates such as 4 L/min improve the DE in the left maxillary sinus and the use of 3 µm particles enhances the DE in the right maxillary sinus as well as the overall total maxillary drug delivery.

Perspectives

I am delighted to collaborate and publish this article with colleagues with whom I have had extensive collaborations. This article also provides new suggestions on how to improve the bi-directional nasal drug delivery with pulsating nebulizers.

Ali Farnoud
Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren

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This page is a summary of: Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery, Physics of Fluids, October 2020, American Institute of Physics, DOI: 10.1063/5.0024264.
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