What is it about?

The deterministic lateral displacement (DLD) method has gradually moved beyond the separation of spherical rigid particles and has been successfully applied to the field of biological cells, especially to the separation of disc-shaped flexible erythrocytes. Different shapes of micropillars in the DLD device significantly affect the sorting performance of erythrocytes. We investigated the effect of the flow field in the gap of micropillars of different shapes (circular, triangular, I-shaped) on the behavior of erythrocyte tumbling motion.

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Why is it important?

The simulation results showed that in the I-shaped pillar DLD device, compared with the circular and triangular pillars, the erythrocytes exhibited a stable and continuous flipping motion during the movement along the array offset direction, which enabled the effective separation size to be maintained at a high level.

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This page is a summary of: Investigating the impact of pillar shape on flexible erythrocyte separation through deterministic lateral displacement, AIP Advances, March 2024, American Institute of Physics,
DOI: 10.1063/5.0203436.
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