What is it about?
Glutaraldehyde is the gold standard for the production of biological aortic valve prostheses containing xenogenic tissue like bovine pericardium. But treatment with glutaraldehyde causes early calcification and deterioration of bioprostheses. We tested the potential of new pretreatment for bioprosthetic materials for cardiac surgery. What's more, we share large original #bioimaging #histology data + #REMBI annotations in the faculty's #OMERO instance.
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Why is it important?
We show biocompatibility and low calcification potential suggesting the presented treatment protocol as promising candidate to develop cutting-edge cardiovascular– and valvular biomaterials in reconstructive surgery.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. Especially the possibility to provide free access to histological images via OMERO and following FAIR principles for scientific data management was awesome. Big thanks again to the team from I3D:bio project, the consortium NFDI4BIOIMAGE and our local core facility cellular imaging and IT department at the TU Dresden for the great support and the inspiring, extremely pleasant teamwork.
Anett Jannasch
Technische Universitat Dresden
Read the Original
This page is a summary of: In vivo application of a glutaraldehyde-free, UVA/riboflavin cross-linked bovine pericardium confirms suitability for cardiovascular substitutes, APL Materials, January 2024, American Institute of Physics,
DOI: 10.1063/5.0182672.
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