What is it about?

3D bioprinting could help us fabricate transformative medical technologies including replacement organs made from a patient's own cells or tissue mimics that we can use to test new medical treatments. In the most common bioprinting techniques, cells travel through a nozzle onto a platform or into a support bath. Cells can be damaged as they travel through the nozzle, but there are a few known strategies that can protect cells while they're in the nozzle: a larger nozzle, a tapered nozzle, a slower print speed, or a lower ink viscosity. However, we find that some of these strategies can also lead to lower quality prints. Using simulations, we evaluate the trade-offs between print quality and cell survival.

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Why is it important?

This paper provides recommendations to the bioprinting community about how to protect cells while still achieving high quality prints. In most cases, a slower print speed and lower ink and support viscosity will protect cells without impacting print quality.

Read the Original

This page is a summary of: Simulated stress mitigation strategies in embedded bioprinting, Physics of Fluids, August 2022, American Institute of Physics,
DOI: 10.1063/5.0102573.
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